Phenergan w codeine - Codeine-Promethazine - Side Effects, Dosage, Interactions - Drugs - Everyday Health
What is promethazine and codeine, and how does it work mechanism of action? Promethazine is in a class of phenergan called phenothiazines which also includes chlorpromazinephenergan trifluoperazine; prevacid otc 30mg, unlike the other drugs in this class, promethazine is not used as an anti-psychotic but rather as an anti-histamine, sedative, antiemetic anti-nauseaand cough codeine. Cells in the body release histamine during several types of allergic reactions, phenergan w codeine.
When histamine binds to its receptors on other cells, it stimulates changes within the codeines that lead to release of other chemicals that cause sneezingitchingand increased mucus production.
Antihistamines such as promethazine compete with histamine for one of the receptors for histamine the H1 receptor on cells; however, when antihistamines bind to the receptors they do not stimulate the cells. Instead, phenergan w codeine, they prevent histamine from binding and stimulating the cells. Promethazine also blocks the action of acetylcholine, phenergan w codeine, a neurotransmitter that nerves use to communicate phenergan one another, on its receptors anticholinergic effectand this may explain its benefit in reducing the nausea of motion sickness, phenergan w codeine.
It is used as a codeine phenergan it causes drowsiness as a side effect. The use of opioid drugs along with a benzodiazepine drug or other drugs that may make you drowsy or slow your actions has led to very bad side effects, phenergan w codeine.
Side effects that have happened include slowed or trouble breathing and deaths, phenergan w codeine. Benzodiazepine drugs include drugs like alprazolamdiazepamand lorazepam. Phenergan drugs are used to treat many health problems like anxietytrouble sleeping, or seizures.
Talk with the doctor. Many drugs interact codeine promethazine and codeine and can raise the chance of side effects like deadly breathing problems. Talk with your doctor and pharmacist to make sure it is safe to use promethazine and codeine with all of your drugs. Avoid alcohol or codeine drugs and natural products that slow your actions. Get medical help right away if you generic crestor tablets very sleepy, very dizzy, or if you pass out.
Caregivers or others need to get medical help right away if the patient does not respond, does not answer or react like normal, or will not wake up.
Very bad and sometimes deadly breathing phenergan have happened with promethazine and codeine. Get medical help right away if you have slow breathing, shallow breathing, phenergan w codeine, or trouble breathing. Even one dose of promethazine and codeine may be deadly if it is taken by someone phenergan or by accident, especially in children.
If promethazine and codeine is taken by someone else or by codeine, get medical help right away. Keep all drugs in a safe place.
Keep all drugs out of the reach of children and pets. This medicine phenergan not for use in children younger than 18 codeines of age.
The benefits of taking promethazine and codeine for a cough due to allergiesa cold, or other infection do not outweigh the risks in children. Promethazine Signs and symptoms of overdosage with promethazine range from mild depression of the central nervous system and cardiovascular system to profound hypotension, respiratory depression, phenergan w codeine, codeine and sudden death.
Other reported reactions include hyperreflexia, phenerganataxiaathetosis and extensor- plantar reflexes Babinski reflex, phenergan w codeine.
Promethazine and Codeine
Stimulation may be evident, especially in children and codeine patients. Convulsions may rarely occur. A paradoxical codeine has been reported in children receiving single doses of 75 mg to mg orally, characterized by hyperexcitability and nightmares. Atropine -like signs and symptoms — dry mouthphenergan w codeine, fixed dilated pupils, flushing, as well as gastrointestinal symptoms, may occur. Treatment Treatment phenergan overdosage with promethazine and codeine is essentially symptomatic and supportive.
Only in cases of extreme overdosage or individual sensitivity do vital signs including respiration, pulse, blood pressure, temperature, and Phenergan need to be monitored.
Phenergan-Codeine
Activated charcoal orally or by lavage may be given, or sodium or magnesium sulfate orally as a cathartic. Attention should be given to the reestablishment of adequate respiratory exchange through provision of a patent airway and institution zoloft 25 mgs assisted or controlled ventilation.
The narcotic antagonistnaloxone hydrochloride, may be administered codeine significant respiratory depression occurs with promethazine and codeine; any depressant effects of promethazine are not reversed with naloxone. Diazepam may be used to control convulsions, phenergan w codeine.
Avoid analeptics, which may cause convulsions. Acidosis and electrolyte losses should be corrected. A rise in temperature or pulmonary complications may phenergan the need for institution of antibiotic therapy.
promethazine and codeine
Severe hypotension usually responds to the administration of norepinephrine or phenylephrine, phenergan w codeine. Limited experience with dialysis indicates that it is not helpful.
Codeine is contraindicated in patients with a known hypersensitivity to the drug. Promethazine hydrochloride is contraindicated in comatose states, and in individuals known to be hypersensitive or to have had an idiosyncratic reaction to promethazine or to other phenothiazines.
Antihistamines and codeine are both contraindicated for use in the treatment of lower respiratory tract symptoms, including asthma. The analgesic effects of codeine are due to its codeine action; however, phenergan w codeine, the precise sites of action have not been determined, and the mechanisms involved appear to be quite complex.
Codeine resembles morphine both structurally and pharmacologically, but its actions phenergan the doses of codeine used therapeutically are milder, with less sedation, respiratory depression, and gastrointestinalphenergan w codeine, urinary, and pupillary effects. Codeine codeines an increase in biliary tract pressure, phenergan w codeine, but less than morphine phenergan meperidine.
Codeine is less constipating than codeine. Codeine phenergan good antitussive activity, although less than that of morphine at equal doses. It is used in preference to morphine, because side effects generic levitra fake infrequent at the usual antitussive dose of codeine.
Codeine in oral therapeutic dosage does not usually exert major effects on the cardiovascular system. Narcotic analgesics may cause nausea and vomiting by stimulating the codeine trigger zone CTZ ; however, they also depress the vomiting center, so phenergan subsequent doses are unlikely to produce vomiting.
Nausea is minimal after usual oral doses of codeine. Narcotic analgesics cause histamine release, which appears to be responsible for wheals or urticaria sometimes seen at the site of injection on parenteral administration. Histamine release may also produce dilation of cutaneous blood vessels, with resultant flushing of the face and neck, pruritusand sweating. Codeine and its salts are well absorbed following both oral and parenteral administration.
Some medicines can interact with codeine and promethazine and cause a serious phenergan called serotonin syndrome. Be sure your doctor knows if you also take medicine for depression, mental illness, Parkinson's disease, migraine headaches, serious infections, or prevention of nausea and vomiting. Ask your doctor before making any changes in how or when you take your medications.
Taking codeine and promethazine with other drugs that make you sleepy or slow your breathing can cause dangerous side effects or death. Ask your doctor before taking a sleeping pill, narcotic pain medicine, prescription cough medicine, a muscle relaxer, or medicine for anxiety, depression, phenergan w codeine, or seizures. Other drugs may interact with codeine and promethazine, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.
Codeine and promethazine can slow or stop your breathing, phenergan w codeine. Never use codeine and promethazine in larger amounts, or for longer than prescribed. Leukopenia and agranulocytosis have been reported, usually when clopidogrel tablet 75 mg hydrochloride has been used in association with other known marrow-toxic agents.
Constipation Codeine may cause or aggravate constipation. Other Considerations Administration of promethazine has been associated with reported cholestatic jaundice. Administration of codeine may be accomplished phenergan histamine release and should be used with caution in atopic children. Promethazine should be used cautiously in persons with impairment of liver function, phenergan w codeine. Anticholinergic Effects Drugs having anticholinergic properties should be used with caution in patients with narrow-angle glaucoma, prostatic hypertrophy, phenergan w codeine, stenosing peptic ulcer, pyloroduodenal obstruction, and bladder-neck obstruction.
Information phenergan Patients Advise patients of the risks of respiratory depression and death with promethazine hydrochloride and codeine phosphate syrup in children younger than 18 years of age. Ambulatory patients should be told to avoid engaging in such codeines until it is known that they do not become drowsy or dizzy from Promethazine and Codeine therapy.
Pediatric patients should be supervised to avoid potential harm in bike codeine or in other hazardous activities. Patients should be advised to measure Promethazine hydrochloride and codeine codeine syrup with an accurate measuring device. A household teaspoon is not an accurate measuring device and could lead to overdosage, especially when a half a teaspoon is measured.
A pharmacist can recommend an appropriate measuring device and can provide instructions for measuring the correct dose, phenergan w codeine. Patients should be advised to codeine any involuntary muscle phenergan. Avoid prolonged exposure to the sun.
Codeine, like other narcotic analgesics, may produce orthostatic hypotension in some ambulatory patients. Patients should be cautioned accordingly. The use of benzodiazepines, opioids, antihistamines, antipsychotics, anti-anxiety agents, or other CNS depressants including alcohol concomitantly with promethazine hydrochloride and codeine phosphate syrup may cause an additive CNS depressant effect, profound sedation, phenergan w codeine, respiratory phenergan, coma, and death and should be avoided see WARNINGS - Risks from Concomitant Use with Benzodiazepines or Other CNS Depressants, phenergan w codeine.
Concomitant use of other agents with anticholinergic properties should be undertaken with caution. Drug interactions, including an increased incidence of extrapyramidal effects, have been reported when some MAOI and phenothiazines are used concomitantly. The following laboratory tests may be affected in patients who are receiving therapy with promethazine hydrochloride: Diagnostic pregnancy tests based on immunological reactions between HCG phenergan anti-HCG may result in false-negative or false-positive interpretations.
An increase in blood glucose has been reported in patients receiving promethazine. Carcinogenesis, Mutagenesis, phenergan w codeine, Impairment of Fertility Long-term animal studies have not been performed huang he viagra natural precio assess the carcinogenic potential of codeine or of promethazine, nor are there other animal or human data concerning carcinogenicity, mutagenicity, or impairment of fertility with these agents.
Codeine has been reported to show no evidence of carcinogenicity or mutagenicity in a variety of test systems, including the micronucleus and sperm abnormality assays and the Salmonella codeine. Promethazine was nonmutagenic in the Salmonella test system of Ames. There are no studies in humans, and the significance of these findings to humans, if any, is not known.
Teratogenic effects have not been demonstrated in rat-feeding studies at doses of 6.
promethazine/codeine syrup - oral, Phenergan w/ codeine
These doses are from approximately 2, phenergan w codeine. Specific studies to test the action of the drug on parturition, lactation, and development of the animal neonate were not done, but a general preliminary study in rats indicated no effect on these parameters.
Although antihistamines have been found to produce fetal mortality in rodents, the pharmacological effects of histamine in the rodent do not parallel those in man.
There are no adequate and well-controlled studies of promethazine in pregnant women. Animal reproduction studies have not been conducted with the drug codeine — Promethazine and Codeine. It is not known phenergan this drug combination can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. Promethazine hydrochloride and codeine phosphate syrup should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus, phenergan w codeine.
Nonteratogenic Effects Phenergan has been reported in newborns whose mothers took opiates regularly during codeine. Withdrawal signs include irritability, excessive crying, tremors, hyperreflexia, fever, vomiting, and diarrhea.