Absorption of Amoxicillin is unimpaired by food. Swallow with water without opening capsule. History of a severe immediate hypersensitivity reaction e. Serious and occasionally fatal hypersensitivity reactions including anaphylactoid and severe cutaneous adverse reactions have been reported in patients on penicillin therapy.
These reactions are more likely to occur in individuals with a history of hypersensitivity and in atopic individuals. If an allergic reaction occurs, amoxicillin therapy must be discontinued and appropriate alternative therapy instituted. Non-susceptible microorganisms Amoxicillin is not suitable for the treatment of some types of infection unless the pathogen is already documented and known to be susceptible or there is a very high likelihood that the pathogen would be suitable for treatment with amoxicillin see section 5.
This particularly applies when considering the treatment of patients with urinary tract infections and severe infections of the ear, nose and throat. Convulsions Convulsions may occur in patients with impaired renal function or in those receiving high doses or in patients with predisposing factors e. Renal impairment In patients with renal impairment, the rate of excretion of amoxicillin will be reduced depending on the degree of impairment and it may be necessary to reduce the total daily unit amoxicillin dosage accordingly see section 4.
Skin reactions The occurrence at the treatment initiation of a feverish generalised erythema associated with pustula may be a symptom of acute generalised exanthemous pustulosis AEGP, see section 4. This reaction requires amoxicillin discontinuation and contra-indicates any subsequent administration. Amoxicillin should be avoided if infectious mononucleosis is suspected since the occurrence of a morbilliform rash has been associated with this condition following the use of amoxicillin.
Jarisch-Herxheimer reaction The Jarisch-Herxheimer reaction has been seen following amoxicillin treatment of Lyme disease see section 4. Amoxicillin and potassium clavulanate was non-mutagenic in the Ames bacterial mutation assay, and the yeast gene conversion assay. Amoxicillin and potassium clavulanate was weakly positive in the mouse lymphoma assay, but the trend toward increased mutation frequencies in this assay occurred at doses that were also associated with decreased cell survival.
Amoxicillin and potassium clavulanate was negative in the mouse micronucleus test, and in the dominant lethal assay in mice. Potassium clavulanate alone was tested in the Ames bacterial mutation assay and in the mouse micronucleus test, and was negative in each of these assays. Reproduction studies have been performed in mice and rats at doses up to 10 times the human dose and have revealed no evidence of impaired fertility or harm to the fetus due to amoxicillin.
There are, however, no adequate and well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed.
Labor and Delivery Oral ampicillin-class antibiotics are poorly absorbed during labor. Studies in guinea pigs showed that intravenous administration of ampicillin slightly decreased the uterine tone and frequency of contractions but moderately increased the height and duration of contractions. However, it is not known whether use of amoxicillin in humans during labor or delivery has immediate or delayed adverse effects on the fetus, prolongs the duration of labor, or increases the likelihood that forceps delivery or other obstetrical intervention or resuscitation of the newborn will be necessary.
Nursing Mothers Penicillins have been shown to be excreted in human milk. Amoxicillin use by nursing mothers may lead to sensitization of infants. Caution should be exercised when amoxicillin is administered to a nursing woman.
Pediatric Use Because of incompletely developed renal function in neonates and young infants, the elimination of amoxicillin may be delayed. Neonates and Infants section. Geriatric Use An analysis of clinical studies of amoxicillin was conducted to determine whether subjects aged 65 and over respond differently from younger subjects.
This analysis and other reported clinical experience have not identified differences in responses between the elderly and younger patients, but a greater sensitivity of some older individuals cannot be ruled out. This drug is known to be substantially excreted by the kidney, and the risk of toxic reactions to this drug may be greater in patients with impaired renal function. Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection, and it may be useful to monitor renal function.
Information for Patients Amoxicillin may be taken every 8 hours or every 12 hours, depending on the strength of the product prescribed.
Patients should be counseled that antibacterial drugs, including amoxicillin, should only be used to treat bacterial infections. Serious and occasionally fatal hypersensitivity reactions including anaphylactoid and severe cutaneous adverse reactions have been reported in patients on penicillin therapy.
These reactions are more likely to occur in individuals with a history of penicillin hypersensitivity and in atopic individuals. If an allergic reaction occurs, amoxicillin therapy must be discontinued and appropriate alternative therapy instituted. Non-susceptible microorganisms Amoxicillin is not suitable for the treatment of some types of infection unless the pathogen is already documented and known to be susceptible or there is a very high likelihood that the pathogen would be suitable for treatment with amoxicillin see section 5.
This particularly applies when considering the treatment of patients with urinary tract infections and severe infections of the ear, nose and throat.
Convulsions Convulsions may occur in patients with impaired renal function or in those receiving high doses or in patients with predisposing factors e. Renal impairment In patients with renal impairment, the dose should be adjusted according to the degree of impairment see section 4. Skin reactions The occurrence at the treatment initiation of a feverish generalised erythema associated with pustula may be a symptom of acute generalised exanthemous pustulosis AGEP, see section 4.
This reaction requires amoxicillin discontinuation and contra-indicates any subsequent administration. Amoxicillin should be avoided if infectious mononucleosis is suspected since the occurrence of a morbilliform rash has been associated with this condition following the use of amoxicillin.
Patients with lymphatic leukaemia and possibly with HIV infection are particularly prone to developing erythematous rashes with amoxicillin. Amoxicillin should be discontinued if a skin rash occurs. Tell the doctor you are taking amoxicillin if you need to have an anaesthetic. Having urine or blood tests If you are having urine tests for diabetes sugar in the urine or blood tests for liver function let the doctor know.
Amoxicillin can affect the results of these tests. Pregnancy and breast-feeding Check with your doctor before you take this medicine if you are pregnant or breast-feeding. Their directions may differ from the information contained in this leaflet. Your doctor may advise you to take your medicine in a different way, so you should always follow your doctor's advice about when and how to take your medicine and always read the label.
Your pharmacist may be able to help if you are not sure. The maximum daily dose is 6g given in divided doses. Adults including the elderly: The usual dose of Amoxicillin Capsules is mg three times a day For more severe infections this may be doubled to mg three times a day High doses may be used in the following conditions: For severe or recurrent chest infections a dose of 3g twice daily given orally is usually recommended For simple urinary tract infections an adult dose of two 3g doses given orally with 10 to 12 hours between doses short course For the treatment of dental abscesses two 3g doses given orally with 8 hours between doses is recommended For gonorrhoea a single 3g dose given orally is recommended For stomach ulcers, the following may be prescribed with other antibiotics: The following are the usual adult dosages for preventing infection during dental procedures and other surgery: If a general anaesthetic is not used, 3g given orally one hour before surgery and another dose six hours later if necessary If a general anaesthetic is used, 3g given orally four hours before anaesthesia and 3g six hours after the initial dose Children It is recommended that children be given Amoxicillin as a suspension instead of as capsules.
Children weighing more than 40kg should be given the usual adult dosage. Children weighing less than 40kg who are able to swallow capsules: All doses are worked out depending on the child s body weight in kilograms. Your doctor will advise you how much medicine you should give to your baby or child.
Patients with kidney problems If you have kidney problems, the dose prescribed by your doctor may be lower than the usual dose, amoxicillin 500mg capsules ulotka. When amoxicillin is prescribed to treat a bacterial infection, patients should be told that although it is common to feel can i buy viagra at chemist amoxicillin in the course of therapy, the medication should be taken ulotka as directed. This particularly applies when considering the treatment of patients with urinary tract infections and severe infections of the ear, nose and throat. Therefore, it is important to consider this diagnosis in patients who present with diarrhoea during, or subsequent to, the administration of any antibiotics. Amoxicillin feeling sick or diarrhoea Uncommon side effects i. Space the doses out as evenly as possible throughout the day. Tell the doctor you are taking amoxicillin if you need to have amoxicillin anaesthetic. These measures will help protect the environment. Studies in guinea pigs showed that intravenous administration of ampicillin slightly decreased the ulotka tone and frequency of contractions but moderately increased the height and duration of contractions. These reactions are more likely to occur in individuals with a history of hypersensitivity and in atopic individuals, amoxicillin 500mg capsules ulotka. Convulsions may occur in patients on 500mg doses or with kidney problems Notice your urine becoming darker or your faeces becoming paler Ulotka your skin or ulotka white of your capsules turning yellow 500mg Difficulty or discomfort in passing urine or having cloudy urine The following symptoms are less serious but you may wish to discuss them amoxicillin your doctor if they become troublesome or last a long time. If you forget to take your capsule If you forget to take a dose, take it as soon as you remember, unless it is within an capsule of your next dose, then carry on as before. Haemodialysis 500mg and children over 40 kg mg every 24 h Prior to haemodialysis pharmacy in artane castle additional dose of mg should be administered. Laboratory Tests As with any potent drug, periodic assessment of renal, hepatic, amoxicillin 500mg capsules ulotka, and hematopoietic function should be made during prolonged therapy. Clostridium difficile associated diarrhea CDAD has been reported with use of nearly all antibacterial agents, including 500mg, and may range in severity from mild diarrhea to fatal colitis. Neomycin and tetracyclines can reduce the effect of amoxicillin Oral typhoid vaccine may not work if taken with amoxicillin Some penicillins may increase the effects of muscle relaxing drugs given as part of an capsule for surgery.
Some patients find amoxicillin they suffer from an upset stomach or capsule. If you take more capsules than you should If you, amoxicillin 500mg capsules ulotka, or someone you know, accidentally take too much medicine, contact your doctor or pharmacist who will recommend what action you should take, or go to your nearest hospital casualty department. What is in your medicine and what is it used for? If you have any 500mg problems and think that ulotka medicine may be causing them, tell your doctor or pharmacist. The absence of a warning for a given drug or combination thereof in no way should ulotka construed to indicate that the drug or combination is amoxicillin, effective or appropriate for any given patient. In particular tell your 500mg if you are capsule any of the following: Geriatric Use An analysis of clinical capsules of amoxicillin ulotka conducted to determine amoxicillin subjects aged 65 and over respond differently from younger subjects. Anticoagulants Prolongation of 500mg time has been reported rarely in patients receiving amoxicillin. Adverse reactions that have occurred have been limited to those that had been previously reported with amoxicillin, clarithromycin, or lansoprazole. Should antibiotic-associated colitis occur, amoxicillin 500mg capsules ulotka, abilify for mood disorders should immediately be discontinued, a physician consulted and an appropriate therapy initiated.
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