Bnf online metformin - What is metformin?
Your blood sugar will need to be checked often, and you may need other blood tests at your doctor's office. Low blood sugar hypoglycemia can happen to everyone who has diabetes. Symptoms include headache, hunger, sweating, confusion, irritability, dizziness, or feeling shaky. Always keep a source of sugar with you in case you have low blood sugar. Sugar sources include fruit juice, hard candy, crackers, raisins, and non-diet soda.
Be sure your family and close friends know how to help you in an emergency. If you have severe hypoglycemia and cannot eat or drink, use a glucagon injection. Your doctor can prescribe a glucagon emergency injection kit and tell you how to use it. Check your blood sugar carefully during times of stress, travel, illness, surgery or medical emergency, vigorous exercise, or if you drink alcohol or skip meals.
These things can affect your glucose levels and your dose needs may also change. Do not change your medication dose or schedule without your doctor's advice. Metformin is only part of a complete treatment program that may also include diet, exercise, weight control, and special medical care. Follow your doctor's instructions very closely. Your doctor may have you take extra vitamin B12 while you are taking metformin. Other clinical data In an open label trial comparing the efficacy and safety of liraglutide 1.
Patients treated with liraglutide had a significant decrease in body weight compared to that of patients treated with sitagliptin Greater proportions of patients treated with liraglutide experienced transient nausea vs patients treated with sitagliptin The reductions in HbA1c and superiority vs sitagliptin observed after 26 weeks of liraglutide treatment 1. Switching patients from sitagliptin to liraglutide after 52 weeks of treatment resulted in additional and statistically significant reduction in HbA1c In an open label trial comparing the efficacy and safety of liraglutide 1.
Both treatments resulted in mean body weight loss of approximately 3 kg. Switching patients from exenatide to liraglutide after 26 weeks of treatment resulted in an additional and statistically significant reduction in HbA1c During the 26 weeks, there were 12 serious events in patients 5. There was no consistent pattern with respect to system organ class of events.
Body weight loss was observed in both treatment arms Gastrointestinal adverse events were more frequently reported with liraglutide treatment Estimated maximum liraglutide concentration was 9.
Liraglutide exposure increased proportionally with dose. Distribution The apparent volume of distribution after subcutaneous administration is 11—17 l. The mean volume of distribution after intravenous administration of liraglutide is 0. This allows your doctor to make sure that you have the dose that is right for you, and also helps to reduce the risk of unwanted side-effects. Try to take metformin at the same time s each day, as this will help you to remember to take it regularly.
Take your doses during a meal or just after a snack. If you have been given modified-release metformin tablets these have the letters 'SR' or 'XL' after the brand name , the tablets are designed to release metformin slowly and evenly.
You must swallow these tablets whole - do not break or chew the tablets, as your body may absorb the metformin too quickly. If you have been given metformin sachets, pour the powder from the sachet into a glass and add ml of water. Stir the solution to mix it, and then drink it straightaway. If you forget to take a dose, make sure that you remember to take your next dose when it is due.
Do not take two doses together to make up for a forgotten dose. Getting the most from your treatment It is important that you keep your regular doctor's and clinic appointments. This is so your progress can be monitored. You will need regular check-ups with an eye clinic and a foot clinic as well as with your doctor and diabetes clinic. Your doctor may recommend that you test for sugar glucose in your blood or urine regularly to check that your diabetes is being controlled.
Your doctor or diabetes nurse will show you how to do this. Do not drink alcohol, as it can affect the control of your blood sugar and can increase the risk of lactic acidosis see below.
If you have been given advice by your doctor about changes to your diet, stopping smoking or taking regular exercise, it is important for you to follow the advice you have been given. Check with your doctor before taking up any new physical exercise, as this will have an effect on your blood sugar levels and you may need to check your blood or urine levels more regularly. Make sure you know what it feels like if your blood sugar is low.
BNF August update This update contains 2 significant changes. BNF July update This update contains 7 significant changes, 6 deleted preparations and 4 new preparations. BNF June update This update contains 8 significant changes and 3 deleted preparations. BNF May update This update contains 3 deleted preparations and 2 new preparations.
BNF April update This update contains 1 significant change, 2 dose changes, 2 deleted preparations and 1 new preparation. Lisdexamfetamine [dose in renal impairment], Tramadol [oral dose for acute and chronic pain] Deleted Preparations: BNF March update This update contains 2 significant changes, 3 dose changes, 1 deleted preparation and 1 new preparation.
For further details on changes in the BNF click on changes. BNF February update This update contains 1 significant change. BNF January update This update contains 7 significant changes, 2 dose changes, 2 deleted preparations and 8 new preparations. BNF December update This update contains 2 significant changes, 4 dose changes, 7 deleted preparations and 9 new preparations.
BNF November Update This update contains 3 significant changes, 2 dose changes, 4 deleted preparations and 6 new preparations. Lubiprostone for treating chronic idiopathic constipation [NICE guidance], Dimethyl fumarate for treating relapsing-remitting multiple sclerosis [NICE guidance], Lenalidomide for treating myelodysplastic syndromes associated with an isolated deletion 5q cytogenetic abnormality [NICE guidance] Dose Changes: BNF October update This update contains 1 significant change, 2 dose changes, 3 deleted preparations and 5 new preparations.
Co-careldopa, Sodium clodronate [dose in renal impairment]. BNF September Update This update contains 6 significant changes, 1 dose change and 3 new preparations. Significant Changes Prasugrel with percutaneous coronary intervention for treating acute coronary syndromes [NICE guidance ], Malaria prophylaxis recommendations for specific countries [update], Ipilimumab for previously untreated advanced unresectable or metastatic melanoma [NICE guidance], Enzalutamide for metastatic hormone-relapsed prostate cancer previously treated with a docetaxel-containing regimen [NICE guidance], Chlorhexidine solutions: BNF August update This update contains 3 significant changes, 2 deleted preparations and 5 new preparations.
BNF July update This update contains 6 significant changes, 5 dose changes, 7 deleted preparations and 10 new preparations. Voriconazole [risk of hepatotoxicity and phototoxicity], Levothyroxine sodium and liothyronine sodium use in pregnancy, Pemetrexed maintenance treatment following induction therapy with pemetrexed and cisplatin for non-squamous non-small-cell lung cancer [NICE guidance], Bortezomib for induction therapy in multiple myeloma before high-dose chemotherapy and autologous stem cell transplantation [NICE guidance], Afatinib for treating epidermal growth factor receptor mutation-positive locally advanced or metastatic non-small-cell lung cancer [NICE guidance], Ophthalmic Specials Guidance [Advice of Royal College of Ophthalmologists and the UK Ophthalmic Pharmacy Group].
BNF June update This update contains 5 significant changes, 2 dose changes, 1 classification change, 4 deleted preparations and 6 new preparations. Dobutamine, Ulipristal acetate [pre-operative treatment of symptoms of uterine fibroids]. BNF May update This update contains 5 significant changes, 6 dose changes, 7 deleted preparations and 3 new preparations.
Haloperidol [significant changes to indications and doses], Domperidone: BNF April update This update contains 4 significant changes, 4 dose changes, 1 new name, 7 deleted preparations and 12 new preparations. Interchangeability of oral mesalazine preparations, Pixantrone monotherapy for treating multiply relapsed or refractory aggressive non-Hodgkin's B-cell lymphoma [NICE guidance], Aflibercept for treating visual impairment caused by macular oedema secondary to central retinal vein occlusion [NICE guidance], Local anaesthetic-induced cardiovascular toxicity [advice on management].
Amoxicillin [paediatric oral dose], Ampicillin [paediatric oral dose], Naloxone [overdosage with opioids], Terbutaline [uncomplicated premature labour]. BNF March Update This update contains 1 significant change, 4 dose changes, 8 deleted preparations and 4 new preparations. Risk of venous thromboembolism with combined hormonal contraceptives. BNF February update This update contains 2 significant changes, 3 dose changes, 1 deleted preparation and 4 new preparations.
Vinflunine for the treatment of advanced or metastatic transitional cell carcinoma of the urothelial tract [NICE guidance], Bosutinib for previously treated chronic myeloid leukaemia [NICE guidance]. BNF January update This update contains 4 significant changes, 3 dose changes, 2 new names, 16 deleted preparations and 5 new preparations. Clostridium difficile infection, Drugs unsafe for use in acute porphyrias, Fluocinolone acetonide intravitreal implant for treating chronic diabetic macular oedema after an inadequate response to prior therapy [NICE guidance], Ranibizumab for treating choroidal neovascularisation associated with pathological myopia [NICE guidance].
Etidronate disodium [formerly Disodium etidronate], Pamidronate disodium [formerly Disodium pamidronate]. BNF December update This update contains 4 significant changes, 5 dose changes, 1 classification change, 9 deleted preparations and 7 new preparations.
Drugs for premature ejaculation [new sub-section] Deleted Preparations: BNF November update This update contains 3 significant changes, 4 dose changes, 4 classification changes, 8 deleted preparations and 3 new preparations.
Benzodiazepine withdrawal advice updated, Metoclopramide: Danazol [hereditary angioedema], Felodipine [prophylaxis of angina], Fenofibrate [dose with concomitant statin], Rifampicin [paediatric dose for prevention of tuberculosis in susceptible close contacts or those who have become tuberculin positive] Classification Changes: Trivalent seasonal influenza vaccines for intramuscular use [title change], Tetravalent seasonal influenza vaccine for intramuscular use [title change], Trivalent seasonal influenza vaccine for intradermal use [title change], Trivalent seasonal influenza vaccine for intranasal use [title change] Deleted Preparations:
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