Risperidone tab 1mg
If you already have diabetes , check your blood sugar regularly as directed and share the results with your doctor. Your doctor may need to adjust your diabetes medication, exercise program , or diet. This drug may also cause significant weight gain and a rise in your blood cholesterol or triglyceride levels.
These effects, along with diabetes, may increase your risk for developing heart disease. Discuss the risks and benefits of treatment with your doctor. See also Notes section.
Risperidone may rarely cause a condition known as tardive dyskinesia. In some cases, this condition may be permanent. This medication may increase a certain natural substance prolactin made by your body. For males, it may result in decreased sexual ability, inability to produce sperm , or enlarged breasts. If you develop any of these symptoms, tell your doctor right away.
Get medical help right away if you have any very serious side effects, including: This medication may rarely cause a very serious condition called neuroleptic malignant syndrome NMS. Get medical help right away if you have any of the following symptoms: Rarely, males may have a painful or prolonged erection lasting 4 or more hours. If this occurs, stop using this drug and get medical help right away, or permanent problems could occur. A very serious allergic reaction to this drug is rare.
However, get medical help right away if you notice any symptoms of a serious allergic reaction , including: This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. In the US - Call your doctor for medical advice about side effects. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at List Risperidone side effects by likelihood and severity.
Precautions Before taking risperidone , tell your doctor or pharmacist if you are allergic to it; or to paliperidone ; or if you have any other allergies. Consider the possibility of multiple drug overdosage. Ensure an adequate airway, oxygenation, and ventilation. Monitor cardiac rhythm and vital signs. Use supportive and symptomatic measures. The chemical designation is 3-[2-[4- 6-fluoro-1,2-benzisoxazolyl piperidinyl]ethyl]-6,7,8,9-tetrahydromethyl-4H-pyrido[1,2-a]pyrimidinone.
The structural formula is: Risperidone is a white to slightly beige powder. It is practically insoluble in water, freely soluble in methylene chloride, and soluble in methanol and 0. However, it has been proposed that the drug's therapeutic activity in schizophrenia could be mediated through a combination of dopamine Type 2 D2 and serotonin Type 2 5HT2 receptor antagonism.
Pharmacokinetics Absorption Risperidone is well absorbed. Plasma concentrations of risperidone, its major metabolite, 9-hydroxyrisperidone, and risperidone plus 9-hydroxyrisperidone are dose proportional over the dosing range of 1 to 16 mg daily 0.
Following oral administration of solution or tablet, mean peak plasma concentrations of risperidone occurred at about 1 hour. Peak concentrations of 9-hydroxyrisperidone occurred at about 3 hours in extensive metabolizers, and 17 hours in poor metabolizers.
Steady-state concentrations of risperidone are reached in 1 day in extensive metabolizers and would be expected to reach steady-state in about 5 days in poor metabolizers.
Steady-state concentrations of 9-hydroxyrisperidone are reached in 5—6 days measured in extensive metabolizers. Food Effect Food does not affect either the rate or extent of absorption of risperidone. Distribution Risperidone is rapidly distributed.
Neither risperidone nor 9-hydroxyrisperidone displaces each other from plasma binding sites. Metabolism Risperidone is extensively metabolized in the liver. The main metabolic pathway is through hydroxylation of risperidone to 9-hydroxyrisperidone by the enzyme, CYP 2D6. A minor metabolic pathway is through N-dealkylation.
The main metabolite, 9-hydroxyrisperidone, has similar pharmacological activity as risperidone. Consequently, the clinical effect of the drug results from the combined concentrations of risperidone plus 9-hydroxyrisperidone.
Side effects The most common and bothersome side effect associated with risperidone is decreased blood pressure while standing up known as orthostatic hypotension. This can cause dizziness or fainting.
A decrease in blood pressure usually occurs early in therapy, while the proper dose is being established. It is more common in older patients than in younger ones. Usually, this side effect disappears entirely with time. If it continues, the physician may decrease the dose.
Meanwhile, people taking risperidone should be aware of this side effect and get up slowly if they have been sitting for an extended time. The most common nervous system side effects of risperidone include insomnia , agitation, anxiety, and headache.
Early in therapy, patients may experience an inability to think clearly or perform certain tasks that require mental alertness. Antipsychotic drugs, including risperidone, can cause side effects that are similar to the symptoms of Parkinson's disease.
The patient does not have Parkinson's disease, but may have shaking in muscles at rest, difficulty with voluntary movements, and poor muscle tone. Several instruments were used for assessing psychiatric signs and symptoms in these studies, among them the Brief Psychiatric Rating Scale BPRS , a multi-item inventory of general psychopathology traditionally used to evaluate the effects of drug treatment in schizophrenia.
The BPRS psychosis cluster conceptual disorganization, hallucinatory behavior, suspiciousness, and unusual thought content is considered a particularly useful subset for assessing actively psychotic schizophrenic patients. A second traditional assessment, the Clinical Global Impression CGI , reflects the impression of a skilled observer, fully familiar with the manifestations of schizophrenia, about the overall clinical state of the patient.
The results of the trials follow: The most consistently positive responses on all measures were seen for the 6 mg dose group, and there was no suggestion of increased benefit from larger doses. The most consistently positive responses were seen for the 4 mg dose group. The results were generally stronger for the 8 mg than for the 4 mg dose group. All patients met DSM-IV diagnostic criteria for schizophrenia and were experiencing an acute episode at time of enrollment.
In the first trial study 1 , patients were randomized into one of three treatment groups: In all cases, study medication was initiated at 0.
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Information last revised July Pediatric The pharmacokinetics of risperidone and 9-hydroxyrisperidone in children were similar to those in adults after correcting for the difference in body weight. 1mg Zydus Cadila is a tab integrated, global healthcare provider, with strengths all risperidone the pharmaceutical value chain. Steady-state concentrations of 9-hydroxyrisperidone are reached in 5—6 days measured in extensive metabolizers. However, higher doses may contribute to additional side effects. Do not stop taking this medication without consulting your doctor, risperidone tab 1mg. These complications have varied in severity; while in some cases symptoms have been self-limited, in other cases neonates have required intensive care unit support and prolonged hospitalization. In all cases, study medication was initiated at 0, risperidone tab 1mg. Orally disintegrating risperidone tablets contain phenylalanine. Consult your doctor before breast -feeding.
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