Although the interaction between other protease inhibitors and sildenafil has not been studied, their concomitant use is expected to increase sildenafil levels. In a study of healthy male volunteers, co-administration of sildenafil at steady state 80 mg t. Concomitant administration of strong CYP3A4 inducers, such as rifampin, is expected to cause greater decreases in plasma levels of sildenafil.

In healthy male volunteers, there was no evidence of a clinically significant effect of azithromycin mg daily for 3 days on the systemic exposure of sildenafil or its major circulating metabolite. Pharmacokinetic data from patients in clinical trials showed no effect on sildenafil pharmacokinetics of CYP2C9 inhibitors such as tolbutamide, warfarin , CYP2D6 inhibitors such as selective serotonin reuptake inhibitors, tricyclic antidepressants , thiazide and related diuretics, ACE inhibitors, and calcium channel blockers.

These effects on the metabolite are not expected to be of clinical consequence. In Vivo Studies No significant interactions were shown with tolbutamide mg or warfarin 40 mg , both of which are metabolized by CYP2C9. In a study of healthy male volunteers, sildenafil mg did not affect the steady state pharmacokinetics of the HIV protease inhibitors, saquinavir and ritonavir, both of which are CYP3A4 substrates.

Sildenafil at steady state, at a dose not approved for the treatment of erectile dysfunction 80 mg t. Clinical Studies In clinical studies, VIAGRA was assessed for its effect on the ability of men with erectile dysfunction ED to engage in sexual activity and in many cases specifically on the ability to achieve and maintain an erection sufficient for satisfactory sexual activity. VIAGRA was evaluated primarily at doses of 25 mg, 50 mg and mg in 21 randomized, double-blind, placebo-controlled trials of up to 6 months in duration, using a variety of study designs fixed dose, titration, parallel, crossover.

VIAGRA was administered to more than 3, patients aged 19 to 87 years, with ED of various etiologies organic, psychogenic, mixed with a mean duration of 5 years. The studies that established benefit demonstrated improvements in success rates for sexual intercourse compared with placebo. The primary measure in the principal studies was a sexual function questionnaire the International Index of Erectile Function -IIEF administered during a 4-week treatment-free run-in period, at baseline, at follow-up visits, and at the end of double-blind, placebo-controlled, at-home treatment.

Two of the questions from the IIEF served as primary study endpoints; categorical responses were elicited to questions about 1 the ability to achieve erections sufficient for sexual intercourse and 2 the maintenance of erections after penetration. The patient addressed both questions at the final visit for the last 4 weeks of the study. Also collected as part of the IIEF was information about other aspects of sexual function, including information on erectile function, orgasm , desire, satisfaction with intercourse, and overall sexual satisfaction.

Sexual function data were also recorded by patients in a daily diary. In addition, patients were asked a global efficacy question and an optional partner questionnaire was administered. Efficacy Results from Controlled Clinical Studies The effect on one of the major end points, maintenance of erections after penetration, is shown in Figure 6, for the pooled results of 5 fixed-dose, dose-response studies of greater than one month duration, showing response according to baseline function.

Results with all doses have been pooled, but scores showed greater improvement at the 50 and mg doses than at 25 mg. The pattern of responses was similar for the other principal question, the ability to achieve an erection sufficient for intercourse. The titration studies, in which most patients received mg, showed similar results. Figure 6 shows that regardless of the baseline levels of function, subsequent function in patients treated with VIAGRA was better than that seen in patients treated with placebo.

At the same time, on-treatment function was better in treated patients who were less impaired at baseline. Effect of VIAGRA and Placebo on Maintenance of Erection by Baseline Score The frequency of patients reporting improvement of erections in response to a global question in four of the randomized, double-blind, parallel, placebo-controlled fixed dose studies patients of 12 to 24 weeks duration is shown in Figure 7.

These patients had erectile dysfunction at baseline that was characterized by median categorical scores of 2 a few times on principal IIEF questions. One-third to one-half of the subjects in these studies reported successful intercourse at least once during a 4-week, treatment-free run-in period. In many of the studies, of both fixed dose and titration designs, daily diaries were kept by patients.

You should not take Sildenafil more than once a day. Do not take Sildenafil film-coated tablets in combination with Sildenafil orodispersible tablets. You should take Sildenafil about one hour before you plan to have sex. Swallow the tablet whole with a glass of water. If you feel the effect of Sildenafil is too strong or too weak, talk to your doctor or pharmacist.

Sildenafil will only help you to get an erection if you are sexually stimulated. The amount of time Sildenafil takes to work varies from person to person, but it normally takes between half an hour and one hour. You may find that Sildenafil takes longer to work if you take it with a heavy meal.

If Sildenafil does not help you to get an erection, or if your erection does not last long enough for you to complete sexual intercourse you should tell your doctor. If you take more Sildenafil than you should: You may experience an increase in side effects and their severity. Doses above mg do not increase the efficacy. You should not take more tablets than your doctor tells you to. Contact your doctor if you take more tablets than you should.

If you have any further questions on the use of this medicine, ask your doctor or pharmacist. Like all medicines, this medicine can cause side effects, although not everybody gets them.

The side effects reported in association with the use of Sildenafil are usually mild to moderate and of a short duration. If you experience any of the following serious side effects stop taking Sildenafil and seek medical help immediately: Very common may affect more than 1 in 10 people headache. Common may affect up to 1 in 10 people: Uncommon may affect up to 1 in people: Rare may affect up to 1 in people: From post-marketing experience cases of unstable angina a heart condition and sudden death have been reported rarely.

Of note, most, but not all, of the men who experienced these side effects had heart problems before taking this medicine. It is not possible to determine whether these events were directly related to Sildenafil. Reporting of side effects If you get any side effects, talk to your doctor, pharmacist.

SILDENAFIL 100 MG FILM-COATED TABLETS

Similar values for pharmacokinetic parameters were seen in normal volunteers and in the patient population, using a population pharmacokinetic approach. The studies that established benefit demonstrated improvements in success rates for sexual intercourse compared with placebo. Very common may affect more than 1 in 10 people headache, sildenafil de 100mg. These effects on the metabolite are not expected to be of clinical consequence. The patient addressed both questions at the final 100mg for the last 4 weeks of the study. Mean sildenafil plasma concentrations measured after the administration of a single oral dose of mg to healthy male volunteers is depicted below: Viagra had sildenafil effect on saquinavir pharmacokinetics. Based upon measurements of sildenafil in semen sildenafil healthy volunteers 90 minutes after dosing, less than 0. Sexual function data were also recorded by patients in a daily diary. In these studies, involving about patients, analyses of patient diaries showed no effect of VIAGRA on rates of attempted intercourse about 2 100mg weekbut there was clear treatment-related improvement in sexual function: Reporting of side effects If you get any side effects, talk to your doctor, sildenafil de 100mg, pharmacist.

Sildenafil

Tags: tamiflu pharmacy guild cash price for advair will 500mg of metformin help with weight loss cialis buy clenbuterol irbesartan tablets price

© Copyright 2017 Sildenafil - Wikipedia.